Improved Functionality of Exhausted Intrahepatic CXCR5+ CD8+ T Cells Contributes to Chronic Antigen Clearance Upon Immunomodulation

Chronic hepatotropic viral infections are characterized by exhausted CD8+ T cells in the presence of cognate antigen in the liver.The impairment of T cell response limits the control of chronic hepatotropic viruses.Immune-modulatory strategies are attractive options to re-invigorate exhausted T cells.However, in hepatotropic viral infections, the k

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Autophagy in pulmonary fibrosis: friend or foe?

Autophagy is an evolutionarily conserved process where long-lived and damaged organelles are degraded.Autophagy has been widely associated with several ageing-process as well in diseases such as neurodegeneration, cancer and fibrosis, and is now being utilised as a target in these diseases.Idiopathic pulmonary fibrosis (IPF) is a progressive, inter

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